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A continuación se muestran las últimas novedades sobre investigaciones, eventos, actividades y descubrimientos que se llevan a cabo en el Instituto de Productos Naturales y Agrobiología.

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Big Bang
Jueves, 29 Octubre 2020
 Jornadas de Agricultura Sostenible
Jueves, 06 Febrero 2020

Publicaciones recientes

The social value of heritage: Balancing the promotion-preservation relationship in the Altamira World Heritage Site, Spain

The social value of heritage: Balancing the promotion-preservation relationship in the Altamira World Heritage Site, Spain

The designation of World Heritage Sites (WHSs) by UNESCO strengthens the international and national image of heritage destinations in the growing market of cultural tourism. Understanding how different stakeholders interpret the value of cultural heritage is one of the most important assets for balancing the promotion and protection of WHSs. This study draws on the case of the Altamira Prehistoric Cave WHS (Spain), whose preservation is under threat and constant debate. It explores factors determining the social value of heritage, namely: existence, aesthetic, economic, and legacy value. In doing so, this paper contributes to emerging debates on heritage management and tourist destinations. Data were collected using two surveys, one focused on visitors, with a total of 1047 valid surveys, and another on the Spanish population as a WHS host community, with a total of 1000 valid surveys. The analysis of these surveys shows how the existence, aesthetic, economic and legacy value dimensions of cultural heritage can build up brands around WHSs. The social-value dimension of cultural heritage therefore affects the market potential of WHSs, whose market potential is closely related to the education levels of a given society. These findings provide valuable information and insights for academics, destination managers and policy-makers in the debate about the preservation and tourism branding of Altamira. This will allow different stakeholders to identify opportunities to develop synergies between tourism promotion and heritage preservation, to both strengthen the brand image of a WHS and preserve its heritage.

Parga-Dans, Eva; Alonso-González, Pablo; Otero Enríquez, Raimundo

Journal of Destination Marketing & Management 18: 100499 (2020)
Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells

Protective effects of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) against oxidant-induced stress in human colon carcinoma Caco-2 cells

The present study investigated the effect of culture extracts (CB08035-SCA and CB08035-SYP) from Marinobacter hydrocarbonoclasticus (strain CB08035) on cell viability and the potential protective effects attributed to molecular mechanisms underlying antioxidant response to survive oxidative stress injuries. Caco-2 cells were submitted to oxidative stress by treatment with tert-butyl hydroperoxide (t-BOOH). Both extracts prevented cell damage and enhanced activity of antioxidant defenses (NQO1 and GST activities and GSH levels) reduced by treatment with t-BOOH. Increased ROS and caspase 3/7 activity induced by t-BOOH were dose-dependently prevented when cells were treated with the extracts. CB08035-SCA caused up-regulation of Nrf2, AKT1 and Bcl-2 gene expressions. Moreover, CB08035-SCA and CB08035-SYP treatments reduced significantly Bax, BNIP3, APAF1, ERK1, JNK1, MAPK1, NFκB1, TNFα, IL-6, IL-1β and HO-1 gene expressions of apoptosis, proinflammation and oxidative stress induced by t-BOOH. CB08035-SCA and CB08035-SYP CPE extracts confer a significant protection against oxidative insults to cells. Our results show that culture extracts CB08035-SCA and CB08035-SYP from M. hydrocarbonoclasticus (strain CB08035) appeared to have antioxidant potential, based on their ability to protect antioxidant enzymes and mRNA gene expressions linked to apoptosis/oxidative pathways. These results suggest that culture extracts CB08035-SCA and CB08035-SYP can be a potential ingredient in the pharmaceutical and cosmeceutical industries.

Martínez, María-Aránzazu; Ares, Irma; Martínez, Marta; López-Torres, Bernardo; Rodríguez, José-Luis; Maximiliano, Jorge-Enrique; Martínez-Larrañaga, María-Rosa; Anadón, Arturo; de la Rosa, José-Manuel; Cueto, Mercedes

Food and Chemical Toxicology 145: 111671 (2020)
Saharan Dust Events

Saharan Dust Events in the Dust Belt -Canary Islandsand the Observed Association with in-Hospital Mortality of Patients with Heart Failure

Recent studies have found increases in the cardiovascular mortality rates during poor air quality events due to outbreaks of desert dust. In Tenerife, we collected (2014–2017) data in 829 patients admitted with a heart failure diagnosis in the Emergency Department of the University Hospital of the Canaries. In this region, concentrations of PM10 and PM2.5 are usually low (~20 and 10 g/m3), but they increase to 360 and 115 g/m3, respectively, during Saharan dust events. By using statistical tools (including multivariable logistic regressions), we compared in-hospital mortality of patients with heart failure and exposure to PM10 and PM2.5 during dust and no-dust events. We found that 86% of in-hospital heart failure mortality cases occurred during Saharan dust episodes that resulted in PM10 > 50 g/m3 (interquartile range: 71–96 g/m3). A multivariate analysis showed that, after adjusting for other covariates, exposure to Saharan dust events associated with PM10 > 50 g/m3 was an independent predictor of heart failure in-hospital mortality (OR = 2.79, 95% CI (1.066–7.332), p = 0.03). In conclusion, this study demonstrates that exposure to high Saharan dust concentrations is independently associated with in-hospital mortality in patients with heart failure.

Dominguez-Rodriguez, Alberto; Baez-Ferrer, Néstor; Rodríguez, Sergio; Avanzas, Pablo; Abreu-Gonzalez, Pedro; Terradellas, Enric; Cuevas, Emilio; Basart, Sara

Journal of Clinical Medicine 9(2): 376 (2020)


El blog del IPNA recoge artículos de divulgación sobre los diversos proyectos de investigación desarrollados en el centro, avances en la ciencia y otros temas de interés sobre cultura científica.