Publicaciones

This article provides an overview of the development, structure and activity of various metal complexes with anti-cancer activity. Chemical researchers continue to work on the development and synthesis of new molecules that could act as anti-tumor drugs to achieve more favorable therapies. It is therefore important to have information about the various chemotherapeutic substances and their mode of action. This review focuses on metallodrugs that contain a metal as a key structural fragment, with cisplatin paving the way for their chemotherapeutic application. The text also looks at ruthenium complexes, including the therapeutic applications of phosphorescent ruthenium(II) complexes, emphasizing their dual role in therapy and diagnostics. In addition, the antitumor activities of titanium and gold derivatives, their side effects, and ongoing research to improve their efficacy and reduce adverse effects are discussed. Metallization of host defense peptides (HDPs) with various metal ions is also highlighted as a strategy that significantly enhances their anticancer activity by broadening their mechanisms of action.

The brown bear reintroduction program in the Pyrenees was launched in 1996, once their population was considered extinct in the central parts of the mountain range. The increasing number of livestock casualties caused by bear attacks forced the public administrations to adopt a package of protection measures, which included hiring mountain shepherds to tend the local farmers' flocks during the summer grazing season. Although these measures were deemed to restore age-old communal shepherding practices that had recently been abandoned by bringing together bears, livestock, and shepherds in the high mountain pastures, the bear program has produced an overlap of communal and state-driven territorialities. Drawing attention to the ambiguous position of mountain shepherds within a new pastoralism-conservation network, situated between local farmers and bear program's decision-makers, this article argues that the commons must be taken into consideration as it persists in current times, even within a high-modern territoriality unfolded under different forms of environmentality. The shepherds epitomize the hybridization of different territorialities, situated on the edge of the production-based economy developed by the local farmers and the amenity-based economy behind the bear reintroduction program. There is a shared, though differentiated capitalist view of natural resources. Using the main theories of power in political ecology and taking the variables of 'format, management, governance, and institution' to frame the commons as an enduring local collective farming resource, this article scrutinizes the collision between the two types of capitalism, usually misidentified as a rural-urban divide. It also shows the extent to which the shifting existence of the commons, crystallized through the ambiguous position of the shepherds, may provide us with a fruitful toolkit to better understanding human-wildlife conflicts based on the cleavage between farming and conservationist sectors.

Los animales son parte constitutiva de la vida humana, del mismo modo que nosotros, como animales humanos, pertenecemos de una u otra forma a sus mundos. Es difícil imaginar cómo podríamos definirnos o identificarnos como humanos si no es junto a otros animales. Los estudios humano- animales, un campo académico que ha crecido exponencialmente en las dos últimas décadas, abordan la diversidad de estas relaciones para comprender cómo las imaginamos, experimentamos y, en definitiva, nos dan forma. Este nuevo «giro» en la antropología tensiona tanto el objeto, el método y la representación en la disciplina, como los pilares del proyecto humanista sobre el que se construyó, renovando el interés sobre conceptos como la relación, la agencia, la personalidad, o lo humano, pero también sobre las densas tramas que nos anudan con la historia, el lenguaje, la política, la sociedad o la cultura. Esta tarea requiere una mirada que vaya «más allá de lo humano» y se interese por las influencias y cuidados mutuos, las asimetrías, los vínculos afectivos y las violencias que marcan la convivencia con otros seres. En ese empeño, este volumen presenta quince historias entre humanos y animales que se dan a lo largo y ancho del Estado español. Todas ellas exploran caminos donde las contingencias, los desafíos, los problemas y los devenires no son solo humanos, y donde una diversidad de criaturas (perdices, gallos, atunes, toros, gatos, perros, osos, lobos, ovejas, caballos, vacas, cabras, cerdos, jabalíes o primates, entre otros) muestran su alteridad en la conformación de los mundos sociales.

We describe the hitherto unknown male of Centromerus fuerteventurensis Wunderlich, 1992 and present new illustrations of the epigyne and vulva. We also provide an update on the known distribution of this species on the Canary Islands.

Fernández-Palacios, José María; Otto, Rüdiger; Capelo, Jorge; Caujapé-Castells, Juli; Nascimento, Lea de; Duarte, Maria Cristina; Elias, Rui B.; García-Verdugo, Carlos; Menezes de Sequeira, Miguel; Médail, Frédéric; Naranjo-Cigala, Agustín; Patiño, Jairo; Price, Jonathan; Romeiras, Maria M.; Sánchez-Pinto, Lázaro; Whittaker, Robert J.

A key to understanding the properties of functional molecules is to determine their conformation in solution. A conformational analysis procedure that relies on quantum mechanical calculations and the widely used DP4+ probability was evaluated to decipher the structural information encoded in NMR chemical shifts. The results underscore the potential utility of using NMR chemical shifts in advancing conformational analysis studies of complex molecules in solution.

Within vertebrates, reptiles are good island colonisers, often leading to considerable levels of intraspecific diversity among populations inhabiting different islands/archipelagos. This study explores the mitochondrial phylogeographic structure of Tarentola boettgeri, a gecko species endemic to the Macaronesian archipelagos of Selvagens and the Canary Islands. Our research introduces a novel monophyletic group, comprising the populations from the islands of Selvagem Pequena and Ilhéu de Fora. Furthermore, we confirm the previously identified genetic clusters associated with Selvagem Grande, Gran Canaria and El Hierro. We estimate that the origin of T. boettgeri dates to the upper Miocene (ca. 6.4 Mya), and that the separation of T. boettgeri bischoffi on Selvagem Grande, Selvagem Pequena, and Ilhéu de Fora, occurred ca. 0.5 Mya. The absence of genetic differences between Selvagem Pequena and Ilhéu de Fora suggests recent gene flow or founder events, possibly facilitated by land connections during major glaciations. Conversely, the geographic barriers between Selvagem Grande and Selvagem Pequena likely persisted, preventing genetic admixing. The significant genetic distances observed among all populations underscore the necessity of an integrative taxonomic revision for T. boettgeri. In light of our findings, and with particular consideration of the small population sizes of T. boettgeri bischoffi on Selvagem Pequena and Ilhéu de Fora, we propose that the identified monophyletic groups should be managed as Evolutionarily Significant Units (ESUs). Accordingly, our study highlights the importance of recognizing ESUs in island-restricted reptile populations for targeted conservation efforts, especially given their unique intraspecific diversity and the vulnerability of their habitats.

Climate change can alter precipitation patterns, disrupting the natural water cycle and generating drought periods that negatively impact crop yield or plant survival. Novel biotechnological approaches are being developed to face water deficits. Specifically, molecular knowledge of the plant hormone abscisic acid (ABA) can be harnessed to develop genetic and chemical approaches to cope with abiotic stress. ABA receptor agonists are promising molecules that activate ABA signaling on demand and show long-lasting effects, in contrast to the exogenous application of ABA, which has a short half-life. In this work, we studied the effect of the iSB09 agonist on tomato plants grown under drought stress or well-watered conditions. iSB09 treatment induced stomatal closure in tomato through activation of PYL1-like and PYL4-like ABA receptors. Additionally, RNA-seq analyses reveal coordinated upregulation by ABA or iSB09 of the genes encoding enzymes involved in the synthesis of the osmoprotective galactinol and raffinose family of oligosaccharides. Foliar spraying of iSB09 under drought conditions anticipated the regulation of transpiration, promoted drought avoidance and increased water use efficiency in tomato plants. Physiological analysis of agonist-treated plants reveals increased CO2 assimilation and effective quantum yield of the photosystem II under drought conditions in iSB09-treated plants compared to mock-treated. Faster regulation of transpiration at the start of the drought period was achieved by iSB09 treatment, and, as a result, water consumption was reduced compared to mock-treated plants. Overall, the agonist treatment mounts the genome-wide transcriptional response to stress and increases water use efficiency under drought conditions and plant protection.

Montane oceanic islands possess unique geographic and ecological attributes, rendering them valuable for assessing patterns and drivers of alpha and beta taxonomic, functional, and phylogenetic diversity along elevational gradients. Such comparisons of diversity facets can provide insights into the mechanisms governing community assembly on islands. Herein, we aimed to characterize taxonomic, functional, and phylogenetic bryophyte diversity on Madeira Island within and across areas at varying elevations. We also assessed how these diversity facets for the alpha and beta components relate to ecological and anthropogenic factors. We estimated and compared alpha and beta taxonomic, functional, and phylogenetic diversity using 80 plots of 0.5 m × 0.5 m across the whole elevational gradient of the island. We compiled trait databases and supplemented them with our own observations. Phylogenetic information was sourced from the Moss and Liverwort Tree of Life. To assess the impact of ecological and anthropogenic factors on the three facets, we applied linear mixed-effects models and generalized dissimilarity models to alpha- and beta-diversity matrices, respectively. All facets of diversity exhibited strong correlations within both mosses and liverworts, indicating a substantial congruence when alpha and beta are analyzed separately. The bryophyte groups categorized by the growth form demonstrated contrasting patterns, aligning with their distinctive ecological requirements. While a mid-elevation peak emerged as a common pattern across the three facets of alpha diversity, beta diversity often displayed the opposite trend. Although the relative influence of environmental factors varied depending on the diversity facet and bryophyte grouping considered, we found that alpha and beta diversity of bryophytes are more influenced by climatic factors and the predominant type of vegetation than by anthropogenic factors. In the current context of global change, these results should be interpreted with caution, but they point to the resilience of bryophytes to survive in relatively well-preserved natural microhabitats within anthropogenic landscapes. In this study on Madeira Island, we investigated patterns and drivers of alpha and beta taxonomic, functional, and phylogenetic diversity along elevational gradients. We found that alpha and beta diversity of bryophytes are more strongly influenced by climatic factors and the predominant type of vegetation than by anthropogenic factors.

The continuous search for natural product-based biopesticides from fungi isolated from untapped sources is an effective tool. In this study, we studied a pre-selected fungal endophyte, isolate Aa22, from the medicinal plant Artemisia absinthium, along with the antifungal, insect antifeedant and nematicidal compounds present in the extract. The endophyte Aa22 was identified as Stemphylium solani by molecular analysis. The antifungal activity was tested by broth microdilution against Fusarium solani, F. oxysporum, F. moniliforme and Botrytis cinerea, the insect antifeedant by choice bioassays against Spodoptera littoralis, Myzus persicae and Rhopalosiphum padi and the in vitro mortality against the root-knot nematode Meloiydogyne javanica. The structures of bioactive compounds were determined on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The ethyl acetate extract obtained from the solid rice fermentation showed mycelial growth inhibition of fungal pathogens (EC50 0.08–0.31 mg/mL), was antifeedant to M. persicae (99%) and nematicidal (68% mortality). A bioguided fractionation led to the isolation of the new compound stempholone A (1), and the known stempholone B (2) and stemphol (3). These compounds exhibited antifeedant (EC50 0.50 mg/mL), antifungal (EC50 0.02–0.43 mg/L) and nematicidal (MLD 0.5 mg/mL) activities. The extract activities can be explained by 3 (antifungal), 1–3 (antifeedant) and 1 (nematicidal). Phytotoxicity tests on Lolium perenne and Lactuca sativa showed that the extract and 1 increased L. sativa root growth (121–130%) and 1 reduced L. perenne growth (48–49%). These results highlight the potential of the endophytic fungi Aa22 as biotechnological source of natural product-based biopesticides.