Publicaciones

Esta sección incluye una lista de los últimos artículos científicos del IPNA publicados en revistas incluidas en el Science Citation Index (SCI).

En DIGITAL.CSIC, repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos desde 1962, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc. del centro. El objetivo de DIGITAL.CSIC es organizar, preservar y difundir en acceso abierto los resultados de nuestra investigación.

En el repositorio institucional del CSIC, pueden encontrar el listado completo de artículos científicos, así como otras colecciones de interés como congresos, tesis, libros, material divulgativo, etc.

Ir a Digital - CSIC

 

Análisis de la Producción Científica del IPNA 2014-2019: análisis bibliométrico realizado a partir de datos recogidos en Scopus y Web of Science.

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Catalytic Hydrocyanation of Activated Terminal Alkynes

A universal, practical and scalable organocatalytic hydrocyanation manifold to provide ß¿substituted acrylonitriles bearing an electron¿withdrawing functionality has been implemented. The catalytic manifold operates under the reactivity generation principle ¿a good nucleophile generates a strong base¿, and it uses 1,4¿diazabicyclo[2.2.2]octane (DABCO) as the catalyst, activated terminal alkynes as substrates and acetone cyanohydrin as the cyanide source. The acrylonitriles obtained as E,Z mixtures are straightforwardly resolved by simple flash chromatography delivering the pure isomers in preparative amounts.

Tejedor, David ; Delgado-Hernández, Samuel; Colella, Lucía; García-Tellado, Fernando 

Chemistry - A European Journal 25(66): 15046-15049 (2019)
DOIDigital.CSIC

Do mosses really exhibit so large distribution ranges? Insights from the integrative taxonomic study of the Lewinskya affinis complex (Orthotrichaceae, Bryopsida)

The strikingly lower number of bryophyte species, and in particular of endemic species, and their larger distribution ranges in comparison with angiosperms, have traditionally been interpreted in terms of their low diversification rates associated with a high long-distance dispersal capacity. This hypothesis is tested here with Lewinskya affinis (≡ Orthotrichum affine), a moss species widely spread across Europe, North and East Africa, southwestern Asia, and western North America. We tested competing taxonomic hypotheses derived from separate and combined analyses of multilocus sequence data, morphological characters, and geographical distributions. The best hypothesis, selected by a Bayes factor molecular delimitation analysis, established that L. affinis is a complex of no less than seven distinct species, including L. affinis s.str., L. fastigiata and L. leptocarpa, which were previously reduced into synonymy with L. affinis, and four new species. Discriminant analyses indicated that each of the seven species within L. affinis s.l. can be morphologically identified with a minimal error rate. None of these species exhibit a trans-oceanic range, suggesting that the broad distributions typically exhibited by moss species largely result from a taxonomic artefact. The presence of three sibling western North American species on the one hand, and four Old World sibling species on the other, suggests that there is a tendency for within-continent diversification rather than recurrent dispersal following speciation. The faster rate of diversification as compared to intercontinental migration reported here is in sharp contrast with earlier views of bryophyte species with wide ranges and low speciation rates.

Vigalondo, B.; Garilleti, R.; Vanderpoorten, A.; Patiño, Jairo; Draper, I.; Calleja, J.A.; Mazimpaka, V.; Lara, F.

Molecular Phylogenetics and Evolution 140: 106598 (2019)
DOIDigital.CSIC

A topoclimate model for Quaternary insular speciation

[Aim]: Understanding the drivers of speciation within islands is key to explain the high levels of invertebrate diversification and endemism often observed within islands. Here, we propose an insular topoclimate model for Quaternary diversification (ITQD), and test the general prediction that, within a radially eroded conical island, glacial climate conditions facilitate the divergence of populations within species across valleys. [Location]: Gran Canaria, Canary Islands. [Taxon]: The Laparocerus tessellatus beetle species complex (Coleoptera, Curculionidae). [Methods]: We characterize individual-level genomic relationships using single nucleotide polymorphisms produced by double-digest restriction site associated DNA sequencing (ddRAD-seq). A range of parameter values were explored in order to filter our data. We assess individual relatedness, species boundaries, demographic history and spatial patterns of connectivity. [Results]: The total number of ddRAD-seq loci per sample ranges from 4,576 to 512, with 11.12% and 4.84% of missing data respectively, depending on the filtering parameter combination. We consistently infer four genetically distinct ancestral populations and two presumed cases of admixture, one of which is largely restricted to high altitudes. Bayes factor delimitation support the hypothesis of four species, which is consistent with the four inferred ancestral gene pools. Landscape resistance analyses identified genomic relatedness among individuals in two out of the four inferred species to be best explained by annual precipitation during the last glacial maximum rather than geographic distance. [Main conclusions]: Our data reveal a complex speciation history involving population isolation and admixture, with broad support for the ITQD model here proposed. We suggest that further studies are needed to test the generality of our model, and enrich our understanding of the evolutionary process in island invertebrates. Our results demonstrate the power of ddRAD-seq data to provide a detailed understanding of the temporal and spatial dynamics of insular biodiversity.

García-Olivares, Victor; Patiño, Jairo; Overcast, Isaac; Salces-Castellano, Antonia; López de Heredia, Unai; Mora-Márquez, Fernando; Machado, Antonio; Hickerson, Michael J.; Emerson, Brent C.

Journal of Biogeography 46(12): 2769-2786 (2019)
DOIDigital.CSIC

Graminoid invasion in an insular endemism hotspot and its protected areas

Invasive plant species are increasingly altering species composition and the functioning of ecosystems from a local to a global scale. The grass species Pennisetum setaceum has recently raised concerns as an invader on different archipelagos worldwide. Among these affected archipelagos are the Canary Islands, which are a hotspot of endemism. Consequently, conservation managers and stakeholders are interested in the potential spreading of this species in the archipelago. We identify the current extent of the suitable habitat for P. setaceum on the island of La Palma to assess how it affects island ecosystems, protected areas (PAs), and endemic plant species richness. We recorded in situ occurrences of P. setaceum from 2010 to 2018 and compiled additional ones from databases at a 500 m × 500 m resolution. To assess the current suitable habitat and possible distribution patterns of P. setaceum on the island, we built an ensemble model. We projected habitat suitability for island ecosystems and PAs and identified risks for total as well as endemic plant species richness. The suitable habitat for P. setaceum is calculated to cover 34.7% of the surface of La Palma. In open ecosystems at low to mid elevations, where native ecosystems are already under pressure by land use and human activities, the spread of the invader will likely lead to additional threats to endemic plant species. Forest ecosystems (e.g., broadleaved evergreen and coniferous forests) are not likely to be affected by the spread of P. setaceum because of its heliophilous nature. Our projection of suitable habitat of P. setaceum within ecosystems and PAs on La Palma supports conservationists and policymakers in prioritizing management and control measures and acts as an example for the potential threat of this graminoid invader on other islands.

Walentowitz, Anna J.; Irl, S.D.H.; Acebedo Rodríguez, Aurelio Jesús; Palomares-Martínez, Ángel; Vetter, Vanessa; Zennaro, Barbara; Medina, Félix M. ; Beierkuhnlein, Carl

Diversity 11(10): 192 (2019)
DOIDigital.CSIC

Chemical composition and biological activities of artemisia pedemontana subsp. assoana essential oils and hydrolate

Given the importance of the genus Artemisia as a source of valuable natural products, the rare plant Artemisia pedemontana subspecies assoana, endemic to the Iberian Peninsula, has been experimentally cultivated in the greenhouse and aeroponically, to produce biomass for essential oil (EO) extraction. The chemical composition of the EOs was analyzed, and their plant protection (insects: Spodoptera littoralis, Rhopalosiphum padi, and Myzus persicae; plants: Lactuca sativa and Lolium perenne; fungi: Aspergillus niger; and nematode: Meloidogyne javanica) and antiparasitic (Trypanosoma cruzi, Phytomonas davidi, and antiplasmodial by the ferriprotoporphyrin biocrystallization inhibition test) properties were studied, in addition to the hydrolate by-product. The EOs showed a 1,8-cineole and camphor profile, with quantitative and qualitative chemical differences between the cultivation methods. These oils had moderate insect antifeedant, antifungal, and phytotoxic effects; were trypanocidel; and exhibited moderate phytomonacidal effects, while the hydrolate showed a strong nematicidal activity. Both EOs were similarly antifeedant; the EO from the greenhouse plants (flowering stage) was more biocidal (antifungal, nematicidal, and phytotoxic) than the EO from the aeroponic plants (growing stage), which was more antiparasitic. The major components of the oils (1,8-cineole and camphor), or their 1:1 combination, did not explain any of these effects. We can conclude that these EOs have potential applications as insect antifeedants, and as antifungal or antiparasitic agents, depending on the cultivation method, and that the hydrolate byproduct is a potent nematicidal.

Sainz, Paula; Andrés, Mª Fé ; Martínez-Díaz, Rafael A.; Bailén, María; Navarro-Rocha, Juliana; Díaz, Carmen E.; González-Coloma, Azucena

Biomolecules 9(10): 558 (2019)
DOIDigital.CSIC

Rapid responses against invasive species on islands: Lessons from the introduced Barbary ground squirrel Atlantoxerus getulus in the Canary Islands

Despite efforts to combat invasive species, further measures are still required to prevent their arrival and translocation, especially into biodiverse island ecosystems. Although many governments worldwide have already established protocols to control alien species, the European outermost regions have yet to implement fully effective prevention or rapid response procedures. The numerous translocations of the invasive Barbary ground squirrel Atlantoxerus getulus within the Canary Islands illustrate this problem. From 1996 to 2016 at least 2.1 individuals per year have been moved from Fuerteventura to other islands. If movements of these medium-sized vertebrates are taking place regularly, the number of smaller species transported within the archipelago could potentially be greater. We argue that it is essential to implement stricter strategies for invasive species control in these remote biodiversity-rich islands, including early detection and rapid response, to minimize impacts on native biodiversity.

Medina, Félix M.; López-Darias, Marta; Piquet, Julien C.

Oryx 53(4): 782-786 (2019)
DOIDigital.CSIC

From intentional community to ecovillage: tracing the Rainbow movement in Spain

The Rainbow is a global community that emerged with the hippie movement in the 1960s. Although it originated and largely developed in the USA, it soon expanded to Europe. Due to the political context in Spain, the Rainbow was weak there until the reestablishment of democracy in 1975, when it was spurred by the creation of various communes throughout the country. This paper explores the issue of heritage in one of the earliest and most iconic Rainbow villages in Spain, Matavenero, asking whether notions of heritage emerge in Rainbow contexts. In doing so, it contributes to critical geography of heritage and intentional communities by inquiring into the narratives about the past developed by the community and their use of space and material culture in ways that reproduce forms of segmentarity. Drawing on ethnographic methods and long-term ethnography, the paper demonstrates the absence of the notion of heritage as generally understood in Western capitalist culture and develops the concept of “a-patrimonial” processes to explain this phenomenon.

Alonso González, Pablo; Parga Dans, Eva

Geo Journal 84: 1219-1237 (2019)
DOIDigital.CSIC

A Focused Library of NO-Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions

Cancer is the second leading cause of death worldwide. Herein, a strategy to quickly and efficiently identify novel lead compounds to develop anticancer agents, using green multicomponent reactions followed by antiproliferative activity and structure–activity relationship studies, is described. A second-generation focused library of nitric oxide-releasing compounds was prepared by microwave-assisted Passerini and Ugi reactions. Nearly all compounds displayed potent antiproliferative activities against a panel of human solid tumor cell lines, with 1-phenyl-1-[(tert-butylamino)carbonyl]methyl 3-[(3-phenylsulfonyl-[1,2,5]oxadiazol-4-yl N-oxide)oxy]benzoate (4 k) and N-[1-(tert-butylaminocarbonyl)-1-phenylmethyl]-N-(4-methylphenyl)-3-(3-phenylsulfonyl-[1,2,5]oxadiazol-4-yl N-oxide)oxyphenyl carboxamide (6 d) exhibiting the strongest activity on SW1573 lung cell line (GI=110 and 21 nm) with selectivity indices of 70 and 470, respectively. Preliminary mechanistic studies suggest a relationship between NO release and antiproliferative activity. Our strategy allowed the rapid identification of at least two molecules as future candidates for the development of potent antitumor drugs

Ingold, Marina; Colella, Lucía; Hernández, Paola; Batthyány, Carlos; Tejedor, David; Puerta, Adrian; García-Tellado, Fernando; Padrón, José M.; Porcal, Williams; López, Gloria V.

ChemMedChem 14(18): 1669-1683 (2019)
DOIDigital.CSIC

Phylogenetic inferences on West Mediterranean Ditomina (Coleoptera: Carabidae: Harpalini) based on molecular data

Ditomina is a subtribe of ground beetles included in the large tribe Harpalini, with most species restricted to the Mediterranean basin. To date, affinities within Harpalini have mainly been derived from morphological data, and the placement of several genera within Ditomina has been subject to discussion. In this study we provide a regional molecular phylogeny for Ditomina with representatives from seven of the eight known genera from the West Mediterranean region, the Australian Phorticosomus Schaum, 1862, and selected Harpalini outgroup taxaDNA sequences from two different markers, the mitochondrial protein coding gene cox1 and the nuclear gene ITS2, were sequenced and analysed from 19 taxaMolecular phylogenetic analyses consistently support (i) the sister relationship of genera Carterus Dejean, 1830 and Eocarterus Stichel, 1923; (ii) a close relationship among Ditomus Bonelli, 1810, Tschitscherinellus Csiki, 1906 and Odontocarus Solier, 1835, which form a lineage well separated from Dixus Billberg, 1820; and (iii) the exclusion of Graniger Motschulsky, 1864 and the Australian Phorticosomus from the subtribe Ditomina. In addition, phylogenetic trees indicate a vicariance event for the brachypterous genus Eocarterus on both sides of the Strait of Gibraltar, followed by further geographical differentiation in southern Iberia and northern Morocco. This pattern contrasts with the distribution of various fully winged species of ground beetles on both sides of the same barrier, suggesting the role of dispersal limitation in speciation. Finally, a new key to supraspecific taxa of the Ditomina of the West Mediterranean region is provided.

Andújar, Carmelo; Ruíz, Carlos; Serrano, José

Arthropod Systematics & Phylogeny 77(2): 205-214 (2019)
DOIDigital.CSIC

Exploring the effect of the irradiation time on photosensitized dendrimer-based nanoaggregates for potential applications in light-driven water photoreduction

Fourth generation polyamidoamine dendrimer (PAMAM, G4) modified with fluorescein units (F) at the periphery and Pt nanoparticles stabilized by L-ascorbate were prepared. These dendrimers modified with hydrophobic fluorescein were used to achieve self-assembling structures, giving rise to the formation of nanoaggregates in water. The photoactive fluorescein units were mainly used as photosensitizer units in the process of the catalytic photoreduction of water propitiated by light. Complementarily, Pt-ascorbate nanoparticles acted as the active sites to generate H2. Importantly, the study of the functional, optical, surface potential and morphological properties of the photosensitized dendrimer aggregates at different irradiation times allowed for insights to be gained into the behavior of these systems. Thus, the resultant photosensitized PAMAM-fluorescein (G4-F) nanoaggregates (NG) were conveniently applied to light-driven water photoreduction along with sodium L-ascorbate and methyl viologen as the sacrificial reagent and electron relay agent, respectively. Notably, these aggregates exhibited appropriate stability and catalytic activity over time for hydrogen production. Additionally, in order to propose a potential use of these types of systems, the in situ generated H2 was able to reduce a certain amount of methylene blue (MB). Finally, theoretical electronic analyses provided insights into the possible excited states of the fluorescein molecules that could intervene in the global mechanism of H2 generation.

Martínez, Natalia P.; Inostroza-Rivera, Ricardo; Durán, Boris; Molero, Leonard; Bonardd, Sebastián; Ramírez, Oscar; Isaacs, Mauricio; Díaz Díaz, David; Leiva, Angel; Saldías, César

Nanomaterials 9(9): 1316 (2019)
DOIDigital.CSIC